Semen analysis is usually the firs t s tep in the assessment of male fertility. Although analyzes provide valuable information about male fertility, success of cytoplasmic sperm injection using this method is not predictable. In the recent years, s tudies have shown that sperm quality assessment helps clinicians predict male fertility s tatus based on the expression of biomarkers. To write this article, a comprehensive s tudy was conducted on several RNA transcripts by searching related words on medical information databases by 2018. According to the literature, spermatogenesis based disorders in male infertility have a significant relationship with the expression level of some RNA molecules (like DAZ and PRM1/PRM2 ratio) in semen and tes ticular tissue. Thus, they might be used as predictor biomarkers to evaluate success rate of tes ticular sperm extraction (TESE) procedure, but confirmation of this hypothesis requires more extensive research. By comparing the number of RNAs attributed to each fertility disorder in men, it is possible to trace the causes of disease or return fertility to some infertile patients by regulating the mentioned molecules. Further researches can provide a better unders tanding of the use of RNA expression profiles in the diagnosis and treatment of male infertility.